Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 18/20 | 0.44 |
| ▸ | PPARA | Q07869 | 17/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585488 | 0.86 | PPARG (0.53) | CYP2C19PPARGPPARA | |
| SCHEMBL3312435 | 0.83 | CYP2C19 (0.45) | CYP2C19PPARGPPARA | |
| SCHEMBL11667295 | 0.83 | CYP2C19 (0.45) | CYP2C19PPARGPPARA | |
| SCHEMBL1326852 | 0.82 | CYP2C19 (0.44) | CYP2C19PPARGPPARA | |
| SCHEMBL7329105 | 0.81 | TSHR (0.44) | CYP2C19PPARGPPARA | |
| SCHEMBL3312014 | 0.81 | CYP2C19 (0.42) | CYP2C19PPARGPPARA | |
| SCHEMBL2884339 | 0.77 | ALDH1A1 (0.52) | PPARGPPARA | |
| SCHEMBL10592431 | 0.74 | MEN1 (0.38) | CYP2C19PPARGPPARA | |
| SCHEMBL11115583 | 0.73 | CYP2C19 (0.45) | CYP2C19PPARGPPARA | |
| SCHEMBL8089903 | 0.73 | CYP2C19 (0.39) | CYP2C19PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786128-B2 | Indole or benzimidazole derivatives as CB1 inverse agonists | HOFFMANN-LA ROCHE INC. (US) | 2010-08-31 | — | — | US | disclosed |
| US-20080234290-A1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES AS CB1 INVERSE AGONISTS | BLEICHER KONRAD | 2008-09-25 | — | — | US | disclosed |
| EP-1807398-B1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-06-25 | — | — | EP | disclosed |
| US-7384945-B2 | Indole or benzimidazole derivatives as CB1 inverse agonists | HOFFMANN-LA ROCHE INC. (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1807398-A1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006045478-A1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-04 | — | — | WO | disclosed |
| US-20060089367-A1 | New indole or benzimidazole derivatives as CB1 inverse agonists | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089367-A1 | New indole or benzimidazole derivatives as CB1 inverse agonists | CNR1, CNR2, GPR119 | CYP2C19 259/4885PPARG 76/4885PPARA 142/4885 |
| US-20080234290-A1 | NEW INDOLE OR BENZIMIDAZOLE DERIVATIVES AS CB1 INVERSE AGONISTS | CNR1, CNR2, GPR119 | CYP2C19 259/4885PPARG 76/4885PPARA 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.