SCHEMBL30859547

SCHEMBL30859547

COc1cn(C2CCN(C(=O)OC(C)(C)C)CC2)c(=O)cc1C(=O)N[C@H]1CCC(=O)NC1=O

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 17/20 0.53
DDB1 Q16531 9/20 0.53
MEN1 O00255 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KMT2A Q03164 2/20 0.40
MAPK1 P28482 1/20 0.40
GPR35 Q9HC97 1/20 0.40
GPR55 Q9Y2T6 1/20 0.40
KDM4E B2RXH2 2/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30859603 0.86 CRBN (0.56) CRBNDDB1
SCHEMBL30859565 0.81 STS (0.45) MEN1ALDH1A1KMT2AMAPK1GPR35
SCHEMBL30859613 0.80 ALDH1A1 (0.48) MEN1ALDH1A1KMT2AMAPK1GPR35
SCHEMBL21935469 0.79 CRBN (0.59) CRBNDDB1
SCHEMBL31236077 0.77 CRBN (0.49) CRBNDDB1
SCHEMBL29257856 0.77 CRBN (0.62) CRBNDDB1
SCHEMBL30859583 0.76 DDB1 (0.65) CRBNDDB1ALDH1A1KDM4EMAPT
SCHEMBL30859555 0.76 DDB1 (0.65) CRBNDDB1ALDH1A1KDM4EMAPT
SCHEMBL25631526 0.76 CRBN (0.51) CRBNDDB1THRB
SCHEMBL30720144 0.75 CRBN (0.59) CRBNDDB1MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024073475-A9 CEREBLON LIGANDS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A/ SK LIFE SCIENCE LABS (US) 2025-04-24 WO disclosed
WO-2024073475-A1 CEREBLON LIGANDS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A PROTEOVANT THERAPEUTICS, INC. (US) 2024-04-04 WO disclosed