Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | TDO2 | P48775 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17771762 | 1.00 | ADRB2 (0.52) | ADRB2SLC6A4AOC3AKR1C2AKR1C1 | |
| SCHEMBL15854056 | 1.00 | ADRB2 (0.52) | ADRB2SLC6A4AOC3AKR1C2AKR1C1 | |
| SCHEMBL1338710 | 0.87 | AKR1C2 (0.42) | ADRB2SLC6A4AOC3AKR1C2AKR1C1 | |
| SCHEMBL8750439 | 0.84 | IDO1 (0.43) | AKR1C2AKR1C1IDO1MAPK1HIF1A | |
| SCHEMBL17789895 | 0.84 | ADRB2 (0.46) | ADRB2SLC6A4AOC3IDO1TDO2 | |
| SCHEMBL29671642 | 0.78 | ADRB2 (0.50) | ADRB2SLC6A4AOC3IDO1TDO2 | |
| SCHEMBL8614780 | 0.78 | IDO1 (0.58) | ADRB2SLC6A4AOC3IDO1TDO2 | |
| SCHEMBL11781825 | 0.78 | ADRB2 (0.50) | ADRB2SLC6A4AOC3IDO1TDO2 | |
| SCHEMBL18905322 | 0.77 | AKR1C2 (0.38) | AKR1C2AKR1C1 | |
| SCHEMBL654510 | 0.77 | ADRB2 (0.48) | ADRB2SLC6A4AOC3IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170001990-A1 | PIPERIDINE-DIONE DERIVATIVES | GENENTECH, INC. (US) | 2017-01-05 | — | — | US | disclosed |
| US-9346805-B2 | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-05-24 | — | — | US | disclosed |
| WO-2015140133-A1 | PIPERIDINE-DIONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-09-24 | — | — | WO | disclosed |
| WO-2015142903-A2 | METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES | GENENTECH, INC. (US) | 2015-09-24 | — | — | WO | disclosed |
| US-8722942-B2 | Method for producing biphenyl derivative | TORAY FINE CHEMICALS CO., LTD. (JP) | 2014-05-13 | — | — | US | disclosed |
| EP-2075241-B1 | METHOD FOR PRODUCING A BIPHENYL DERIVATIVE | TORAY FINECHEMICALS CO LTD (JP) | 2013-09-25 | — | — | EP | disclosed |
| US-20100230634-A1 | METHOD FOR PRODUCING BIPHENYL DERIVATIVE | Hayashi, Tamio (JP) | 2010-09-16 | — | — | US | disclosed |
| EP-2075241-A1 | METHOD FOR PRODUCING BIPHENYL DERIVATIVE | Toray Fine Chemicals Co., Ltd. (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009034547-A2 | NEW 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO[3,4-D PYRIMIDINE AND PYRROLO[2,3-D]PYRIMIDINE AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100230634-A1 | METHOD FOR PRODUCING BIPHENYL DERIVATIVE | CYP2E1, DDT, B2M | ADRB2 2561/4885SLC6A4 3842/4885AOC3 1215/4885 |
| US-20170001990-A1 | PIPERIDINE-DIONE DERIVATIVES | DRD4, ADORA1, ADORA3 | ADRB2 144/4885SLC6A4 1120/4885AOC3 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.