Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30864098 | 0.88 | CRBN (0.39) | CRBNDDB1GFERGABRDGABRA1 | |
| SCHEMBL21409346 | 0.83 | GABRD (0.57) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL30266960 | 0.82 | CRBN (0.42) | CRBNDDB1GFERGABRDGABRA1 | |
| SCHEMBL28978031 | 0.82 | CRBN (0.42) | CRBNDDB1GFERGABRDGABRA1 | |
| SCHEMBL30966192 | 0.82 | TNKS (0.46) | CRBNDDB1GFERGABRDGABRA1 | |
| Hydrochloric Acid SCHEMBL31138067 | 0.82 | GABRD (0.56) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL30267149 | 0.81 | CRBN (0.47) | CRBNDDB1GFERGABRDGABRA1 | |
| SCHEMBL30816878 | 0.81 | GABRD (0.42) | CRBNDDB1GFERGABRDGABRA1 | |
| SCHEMBL30816881 | 0.81 | GABRD (0.42) | CRBNDDB1GFERGABRDGABRA1 | |
| SCHEMBL30864002 | 0.80 | GABRD (0.41) | CRBNDDB1GFERGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |