Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30266960 | 1.00 | CRBN (0.42) | CRBNDDB1GFERGABRDGABRA1 | |
| SCHEMBL30816917 | 0.94 | CRBN (0.35) | CRBNDDB1GFERGABRDGABRA1 | |
| SCHEMBL30995353 | 0.91 | DDB1 (0.46) | CRBNDDB1GFERALDH1A1TP53 | |
| SCHEMBL30816865 | 0.90 | TNKS (0.37) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL30864019 | 0.89 | ITGB3 (0.37) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL28978062 | 0.89 | MGLL (0.39) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL30864113 | 0.88 | CRBN (0.40) | CRBNDDB1GFERALDH1A1TP53 | |
| SCHEMBL30816863 | 0.88 | SOS1 (0.42) | CRBNHPGDFFAR4HSD11B1CYP3A4 | |
| SCHEMBL30816861 | 0.88 | SOS1 (0.42) | CRBNHPGDFFAR4HSD11B1CYP3A4 | |
| SCHEMBL30864098 | 0.86 | CRBN (0.39) | CRBNDDB1GFERGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115710274-A | IRAK4 degradation agent, preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2023-02-24 | — | — | CN | disclosed |