Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | FASN | P49327 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28978031 | 0.88 | CRBN (0.42) | CRBNDDB1GFERALDH1A1HPGD | |
| SCHEMBL30266960 | 0.88 | CRBN (0.42) | CRBNDDB1GFERALDH1A1HPGD | |
| SCHEMBL30995353 | 0.86 | DDB1 (0.46) | CRBNDDB1GFERALDH1A1HPGD | |
| SCHEMBL30816917 | 0.82 | CRBN (0.35) | CRBNDDB1GFERALDH1A1HPGD | |
| SCHEMBL30995421 | 0.81 | CRBN (0.38) | CRBNDDB1GFERALDH1A1HPGD | |
| SCHEMBL29319113 | 0.81 | CRBN (0.38) | CRBNDDB1GFERALDH1A1HPGD | |
| SCHEMBL30864098 | 0.80 | CRBN (0.39) | CRBNDDB1GFERALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL30970066 | 0.80 | CRBN (0.37) | CRBNDDB1GFERALDH1A1HPGD | |
| SCHEMBL30816865 | 0.78 | TNKS (0.37) | CRBNDDB1TNKSPARP1PARP10 | |
| SCHEMBL30267149 | 0.78 | CRBN (0.47) | CRBNDDB1GFERHPGDCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |