Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | CCR8 | P51685 | 3/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31677340 | 1.00 | SOS1 (0.41) | SOS1CRBNMLKLCYP2D6USP2 | |
| SCHEMBL30864059 | 0.92 | SOS1 (0.44) | SOS1CRBNMLKLCYP2D6USP2 | |
| SCHEMBL31677307 | 0.92 | SOS1 (0.44) | SOS1CRBNMLKLCYP2D6USP2 | |
| SCHEMBL30148829 | 0.88 | CRBN (0.42) | SOS1CRBNMLKLCYP2D6USP2 | |
| SCHEMBL30863989 | 0.87 | SOS1 (0.42) | SOS1CRBNMLKLCYP2D6USP2 | |
| SCHEMBL30984835 | 0.85 | SOS1 (0.51) | SOS1CRBNMLKLCYP2D6USP2 | |
| SCHEMBL31586864 | 0.85 | ACACB (0.47) | SOS1CRBNMLKLUSP2TSHR | |
| SCHEMBL30267244 | 0.84 | SOS1 (0.42) | SOS1CRBNMLKLCYP2D6USP2 | |
| SCHEMBL30874160 | 0.83 | ACACB (0.47) | CRBNMLKLDDB1KCNH2PARP1 | |
| SCHEMBL31138070 | 0.83 | ROCK2 (0.39) | SOS1CRBNMLKLDDB1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |