Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | CISD2 | Q8N5K1 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25174744 | 1.00 | CFTR (0.44) | CFTRNOTUMCISD2MAPTCYP3A4 | |
| SCHEMBL25187347 | 0.84 | NOTUM (0.46) | CFTRNOTUMMAPTGABRPGABRD | |
| SCHEMBL26121563 | 0.83 | KDM4E (0.33) | CFTRNOTUMGRM5AR | |
| SCHEMBL30634617 | 0.83 | KDM4E (0.33) | CFTRNOTUMGRM5AR | |
| SCHEMBL25201237 | 0.82 | NOTUM (0.40) | CFTRNOTUMCISD2MAPTCYP3A4 | |
| SCHEMBL25180891 | 0.82 | SOS1 (0.46) | CFTRNOTUMCISD2CYP3A4ACHE | |
| SCHEMBL30867275 | 0.82 | NOTUM (0.40) | CFTRNOTUMMAPTCYP3A4ACHE | |
| SCHEMBL29090594 | 0.82 | NOTUM (0.40) | CFTRNOTUMMAPTCYP3A4ACHE | |
| SCHEMBL22208636 | 0.81 | NOTUM (0.42) | CFTRNOTUMCISD2MAPTCYP3A4 | |
| SCHEMBL18985227 | 0.78 | LMNA (0.41) | NOTUMCISD2CYP3A4ACHEGRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4583867-A2 | SODIUM CHANNEL BLOCKING COMPOUNDS, DERIVATIVES THEREOF, AND METHODS OF THEIR USE | Latigo Biotherapeutics, Inc. (US) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054622-A2 | SODIUM CHANNEL BLOCKING COMPOUNDS, DERIVATIVES THEREOF, AND METHODS OF THEIR USE | LATIGO BIOTHERAPEUTICS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |