Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867692 | 0.82 | GRM1 (0.45) | PDK4GRM5GRM1 | |
| SCHEMBL30867684 | 0.81 | MAP4K4 (0.33) | GPR119 | |
| SCHEMBL30867713 | 0.75 | MAP4K4 (0.31) | GPR119 | |
| SCHEMBL30867816 | 0.74 | DDB1 (0.33) | GPR119KDM1ADDB1CRBN | |
| SCHEMBL38653098 | 0.72 | BUB1 (0.31) | BUB1 | |
| SCHEMBL30867920 | 0.71 | GPR119 (0.43) | GPR119DDB1CRBN | |
| SCHEMBL31283409 | 0.70 | GRM1 (0.46) | PDK4GRM5GRM1 | |
| SCHEMBL30867758 | 0.69 | GPR119 (0.38) | GPR119DDB1CRBNGRM5 | |
| SCHEMBL29079980 | 0.68 | PDK4 (0.43) | BUB1PDK4GPR119KDM1AGRM5 | |
| SCHEMBL31282887 | 0.68 | GRM1 (0.44) | PDK4GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |