SCHEMBL30867795

SCHEMBL30867795

Cn1ncc(Br)c1N1CCN(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.49
CKS1B P61024 2/20 0.47
SKP1 P63208 2/20 0.47
SKP2 Q13309 2/20 0.47
GPR119 Q8TDV5 5/20 0.46
MAPT P10636 2/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
MEN1 O00255 1/20 0.44
TSHR P16473 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
KCNH2 Q12809 2/20 0.44
MAP4K4 O95819 1/20 0.43
LRRK2 Q5S007 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30872352 0.85 RET (0.48) RETCKS1BSKP1SKP2GPR119
SCHEMBL30867872 0.84 MAP4K4 (0.48) CKS1BSKP1SKP2GPR119MAPT
SCHEMBL30867889 0.80 MAPT (0.55) CKS1BSKP1SKP2GPR119MAPT
SCHEMBL16522581 0.80 CKS1B (0.51) CKS1BSKP1SKP2GPR119MAPT
SCHEMBL15093969 0.79 CCNK (0.42) RETGPR119MAPT
SCHEMBL26669456 0.78 MAPT (0.48) RETCKS1BSKP1SKP2GPR119
SCHEMBL712231 0.77 GPR119 (0.60) CKS1BSKP1SKP2GPR119MAPT
SCHEMBL16892111 0.77 GPR119 (0.56) CKS1BSKP1SKP2GPR119MAPT
SCHEMBL14801590 0.77 ALDH1A1 (0.51) CKS1BSKP1SKP2GPR119MAPT
SCHEMBL26669464 0.76 GPR119 (0.47) CKS1BSKP1SKP2GPR119MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598917-A1 HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF Amgen Inc. (US) 2025-08-13 EP disclosed
EP-4598916-A1 HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF Amgen Inc. (US) 2025-08-13 EP disclosed
WO-2024076674-A1 HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF AMGEN INC. (US) 2024-04-11 WO disclosed
WO-2024076672-A1 HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF AMGEN INC. (US) 2024-04-11 WO disclosed