Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.44 |
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14801590 | 0.96 | ALDH1A1 (0.51) | MAPTALDH1A1LMNAMETKCNH2 | |
| SCHEMBL14800333 | 0.90 | MAPT (0.47) | MAPTALDH1A1LMNAMETKCNH2 | |
| SCHEMBL14800947 | 0.88 | ALDH1A1 (0.46) | MAPTALDH1A1LMNAMETKCNH2 | |
| SCHEMBL14800774 | 0.87 | MAPT (0.47) | MAPTALDH1A1LMNAMETKCNH2 | |
| SCHEMBL14800507 | 0.87 | LMNA (0.45) | MAPTALDH1A1LMNAMETKCNH2 | |
| SCHEMBL14801209 | 0.87 | MAPT (0.45) | MAPTALDH1A1LMNAMETKCNH2 | |
| SCHEMBL14801493 | 0.87 | MAPT (0.47) | MAPTALDH1A1LMNAMETKCNH2 | |
| SCHEMBL14801032 | 0.86 | ALDH1A1 (0.44) | MAPTALDH1A1LMNAMETKCNH2 | |
| SCHEMBL14800349 | 0.86 | CYP11B2 (0.50) | MAPTALDH1A1LMNAMETGPR119 | |
| SCHEMBL14800169 | 0.86 | MAPT (0.46) | MAPTALDH1A1LMNAMETKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| EP-4598916-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |
| WO-2024076672-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |