SCHEMBL30869424

SCHEMBL30869424

Brc1cnc2c(c1)Oc1cc(Br)cnc1N2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 6/20 0.38
HTT P42858 1/20 0.35
KMT2A Q03164 1/20 0.35
DYRK1A Q13627 6/20 0.35
DYRK1B Q9Y463 3/20 0.33
AURKA O14965 2/20 0.33
DAPK3 O43293 2/20 0.33
JAK2 O60674 2/20 0.33
MAP4K4 O95819 2/20 0.33
PAK4 O96013 2/20 0.33
ABL1 P00519 2/20 0.33
RET P07949 2/20 0.33
FGFR1 P11362 2/20 0.33
PDGFRA P16234 2/20 0.33
FLT1 P17948 2/20 0.33
LTK P29376 2/20 0.33
GRK5 P34947 2/20 0.33
KDR P35968 2/20 0.33
CSNK1A1 P48729 2/20 0.33
CDK8 P49336 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30869620 1.00 AHR (0.38) AHRHTTKMT2ADYRK1ADYRK1B
SCHEMBL30869584 0.84 AHR (0.42) AHRDYRK1ADYRK1BAURKADAPK3
SCHEMBL30869575 0.84 AHR (0.42) AHRDYRK1ADYRK1BAURKADAPK3
SCHEMBL30869747 0.79 AHR (0.32) AHRSMN1; SMN2
SCHEMBL30869709 0.79 AHR (0.32) AHRSMN1; SMN2
SCHEMBL30869696 0.79 MMP12 (0.38) AHRHTTKMT2AALDH1A1MAPT
SCHEMBL859012 0.72 MMP12 (0.38) KMT2ADYRK1ADYRK1BAURKADAPK3
SCHEMBL4098266 0.71 BRD4 (0.32)
SCHEMBL755912 0.71 BRD4 (0.47) DYRK1ADYRK1BAURKADAPK3JAK2
SCHEMBL30524891 0.69 GRM5 (0.36) HTTKMT2ADYRK1ADYRK1BAURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583868-A2 DYNAMIN ACTIVATORS Walden Biosciences, Inc. (US) 2025-07-16 EP disclosed
WO-2024054661-A2 DYNAMIN ACTIVATORS WALDEN BIOSCIENCES (US) 2024-03-14 WO disclosed