Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | TNKS | O95271 | 3/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28514019 | 1.00 | JAK2 (0.47) | JAK2JAK3TNKSTNKS2BRD4 | |
| SCHEMBL12942105 | 0.89 | ALDH1A1 (0.44) | JAK2JAK3TNKSTNKS2MTOR | |
| SCHEMBL16455985 | 0.86 | JAK2 (0.49) | JAK2JAK3TNKSTNKS2MEN1 | |
| SCHEMBL16455916 | 0.83 | TNKS (0.42) | JAK2JAK3TNKSTNKS2MEN1 | |
| SCHEMBL30870514 | 0.79 | KDM4E (0.47) | PIK3CAMTORPRKDCCHRM2CHRM4 | |
| SCHEMBL28503434 | 0.79 | KDM4E (0.47) | PIK3CAMTORPRKDCCHRM2CHRM4 | |
| SCHEMBL29771811 | 0.78 | TNKS (0.52) | JAK2JAK3TNKSTNKS2BRD4 | |
| SCHEMBL23236178 | 0.78 | HSD11B1 (0.47) | TNKSTNKS2PRKDCCHRM2CHRM4 | |
| SCHEMBL23236182 | 0.78 | HSD11B1 (0.47) | TNKSTNKS2PRKDCCHRM2CHRM4 | |
| SCHEMBL2636889 | 0.77 | MEN1 (0.51) | JAK2JAK3TNKSTNKS2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112074511-B | Substituted benzodiazoles and their use in therapy | 托马斯·黑勒戴药物研究基金会 | 2024-04-26 | — | — | CN | disclosed |