Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719769 | 0.92 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1KDM4ESIRT6LMNA | |
| SCHEMBL16003471 | 0.85 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1KDM4ESIRT6LMNA | |
| SCHEMBL30871973 | 0.85 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1KDM4ESIRT6LMNA | |
| SCHEMBL3311685 | 0.83 | LMNA (0.41) | SMN1; SMN2ALDH1A1KDM4ESIRT6LMNA | |
| SCHEMBL1311975 | 0.83 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1KDM4ESIRT6LMNA | |
| SCHEMBL3314688 | 0.80 | LMNA (0.42) | SMN1; SMN2ALDH1A1SIRT6LMNATDP1 | |
| SCHEMBL3311194 | 0.78 | ALDH1A1 (0.42) | ALDH1A1TDP1BLMTSHR | |
| SCHEMBL23653979 | 0.78 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1KDM4ESIRT6LMNA | |
| SCHEMBL22954820 | 0.77 | CHEK1 (0.43) | SMN1; SMN2ALDH1A1SIRT6LMNAMAPT | |
| SCHEMBL4524727 | 0.77 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1KDM4ESIRT6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | SMN1; SMN2 1509/4885ALDH1A1 649/4885KDM4E 2169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.