Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26644600 | 1.00 | TGM2 (0.46) | TGM2CES1NPSR1CDK2KDR | |
| SCHEMBL31108687 | 0.82 | TGM2 (0.45) | TGM2CES1NPSR1CDK2KDR | |
| SCHEMBL31108708 | 0.78 | TGM2 (0.41) | TGM2CES1NPSR1KDRCDK1 | |
| SCHEMBL31015641 | 0.78 | CDK2 (0.40) | TGM2CES1CDK2KDRCDK5 | |
| SCHEMBL28490501 | 0.77 | GABRA1 (0.42) | TGM2CES1NPSR1KDRCDK1 | |
| SCHEMBL31015666 | 0.76 | CDK2 (0.40) | TGM2CES1CDK2KDR | |
| SCHEMBL31015656 | 0.76 | CDK2 (0.40) | TGM2CDK2KDRMEN1KMT2A | |
| SCHEMBL27453741 | 0.75 | KDR (0.38) | TGM2CES1NPSR1CDK2KDR | |
| SCHEMBL31015679 | 0.75 | TLK2 (0.43) | TGM2CDK2KDRCDK5CDK5R1 | |
| SCHEMBL31015728 | 0.74 | CDK2 (0.39) | TGM2CDK2KDRLRRK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119212724-A | Engineered immune effector cells and their use in combination with CBL-b inhibitors | 上海先博生物科技有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-118791465-A | Cbl-b inhibitors | 北京诺诚健华医药科技有限公司 | 2024-10-18 | — | — | CN | disclosed |
| WO-2024212941-A1 | CBL-B INHIBITOR | 北京诺诚健华医药科技有限公司 | 2024-10-17 | — | — | WO | disclosed |
| WO-2024153246-A1 | SUBSTITUTED TRICYCLIC COMPOUND AND USE THEREOF | 海南先声再明医药股份有限公司 | 2024-07-25 | — | — | WO | disclosed |
| CN-117940404-A | Tricyclic compounds as Cbl-b inhibitors | 海南先声再明医药股份有限公司 | 2024-04-26 | — | — | CN | disclosed |