Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 13/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.74 |
| ▸ | USP2 | O75604 | 3/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 5/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2817996 | 0.99 | CYP3A4 (0.72) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| SCHEMBL11955031 | 0.94 | CYP3A4 (0.74) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| Hydrochloric Acid SCHEMBL485450 | 0.93 | CYP3A4 (0.72) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| SCHEMBL13050666 | 0.91 | CYP3A4 (0.60) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| SCHEMBL2834740 | 0.91 | CYP3A4 (0.68) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| Hydrochloric Acid SCHEMBL485785 | 0.90 | CYP3A4 (0.67) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| SCHEMBL13131243 | 0.88 | CYP3A4 (0.83) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| Hydrochloric Acid SCHEMBL2816934 | 0.87 | CYP3A4 (0.81) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| SCHEMBL38664534 | 0.86 | CYP3A4 (0.60) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 | |
| Hydrochloric Acid SCHEMBL30328825 | 0.84 | CYP3A4 (0.97) | CYP3A4CYP2D6ALDH1A1CYP1A2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-8357717-B2 | Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity | GRUENENTHAL GMBH (DE) | 2013-01-22 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| US-20100234340-A1 | Substituted Spiroamide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | CYP3A4 3781/4885CYP2D6 1926/4885ALDH1A1 2086/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | CYP3A4 3781/4885CYP2D6 1926/4885ALDH1A1 2086/4885 |
| US-20100234340-A1 | Substituted Spiroamide Compounds | BDKRB1, BDKRB2, AVPR1B | CYP3A4 1215/4885CYP2D6 950/4885ALDH1A1 1303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.