Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PHKG1 | Q16816 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | PAICS | P22234 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30877418 | 0.87 | RAPGEF4 (0.43) | HTR6RAPGEF4METCA2KDM4E | |
| SCHEMBL30877275 | 0.85 | RAPGEF4 (0.45) | HTR6RAPGEF4CA2KDM4EL3MBTL1 | |
| SCHEMBL30877469 | 0.84 | HTR6 (0.39) | HTR6FLT3METCA2CA12 | |
| SCHEMBL30877318 | 0.80 | RAPGEF4 (0.44) | HTR6RAPGEF4CA2KDM4EGLA | |
| SCHEMBL30877392 | 0.80 | RAPGEF4 (0.48) | HTR6RAPGEF4CA2KDM4EL3MBTL1 | |
| SCHEMBL30877493 | 0.80 | RAPGEF4 (0.40) | HTR6RAPGEF4CA2KDM4EL3MBTL1 | |
| SCHEMBL30877400 | 0.79 | RAPGEF4 (0.40) | HTR6RAPGEF4CA2L3MBTL1CA1 | |
| SCHEMBL30877498 | 0.79 | RAPGEF4 (0.43) | HTR6RAPGEF4FLT3METCA2 | |
| SCHEMBL30877504 | 0.79 | RAPGEF4 (0.43) | HTR6RAPGEF4FLT3METCA2 | |
| SCHEMBL30877474 | 0.76 | RAPGEF4 (0.41) | HTR6RAPGEF4CA2KDM4EJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964643-B | Pyrrole [2,3-b ] pyridine derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-117964643-A | Pyrrole [2,3-b ] pyridine derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-05-03 | — | — | CN | disclosed |