Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26383006 | 0.90 | ALDH1A1 (0.49) | LMNAMAPTALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL30879007 | 0.87 | MAPT (0.44) | LMNAMAPTALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL520092 | 0.87 | LMNA (0.44) | LMNAMAPTALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL30879125 | 0.85 | LMNA (0.45) | LMNAMAPTALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL521221 | 0.79 | SIRT6 (0.53) | LMNAMAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL222267 | 0.78 | MAPT (0.62) | LMNAMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL520652 | 0.78 | KMT2A (0.50) | LMNAMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2205963 | 0.78 | LMNA (0.43) | LMNAALDH1A1SMN1; SMN2L3MBTL1PTBP1 | |
| SCHEMBL30879400 | 0.78 | ALDH1A1 (0.44) | LMNAALDH1A1TDP1L3MBTL1CHEK1 | |
| SCHEMBL3939407 | 0.78 | ALDH1A1 (0.44) | LMNAALDH1A1TDP1L3MBTL1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |