Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.48 |
| ▸ | BTK | Q06187 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 5/20 | 0.41 |
| ▸ | ROS1 | P08922 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878727 | 0.91 | EGFR (0.50) | EGFRBTKFGFR1JAK3IGF1R | |
| SCHEMBL30878436 | 0.90 | EGFR (0.49) | EGFRBTKFGFR1JAK3WEE1 | |
| SCHEMBL30879233 | 0.88 | WEE1 (0.52) | EGFRFGFR1WEE1CDK4FGFR2 | |
| SCHEMBL30878805 | 0.87 | EGFR (0.56) | EGFRBTKFGFR1WEE1IGF1R | |
| SCHEMBL30879218 | 0.85 | EGFR (0.49) | EGFRBTKFGFR1JAK3IGF1R | |
| SCHEMBL30878690 | 0.85 | FGFR4 (0.43) | EGFRBTKFGFR1JAK3WEE1 | |
| SCHEMBL30879105 | 0.84 | FGFR1 (0.46) | EGFRBTKFGFR1JAK3WEE1 | |
| SCHEMBL30878685 | 0.83 | IGF1R (0.54) | EGFRIGF1RALKMAPK7LRRK2 | |
| SCHEMBL30878822 | 0.82 | EGFR (0.49) | EGFRBTKFGFR1JAK3IGF1R | |
| SCHEMBL30878665 | 0.82 | WEE1 (0.49) | EGFRFGFR1WEE1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |