Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | WDR5 | P61964 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | UBE2M | P61081 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.43 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879180 | 0.82 | WDR5 (0.62) | GAAWDR5HTT | |
| SCHEMBL30878872 | 0.81 | AAK1 (0.48) | RAB9AGAAWDR5KMT2AMEN1 | |
| SCHEMBL10126893 | 0.80 | WDR5 (0.56) | GAAWDR5KMT2APOLBKDM4E | |
| SCHEMBL30921393 | 0.79 | MAPT (0.52) | GAAWDR5KMT2AMEN1HTT | |
| SCHEMBL30879250 | 0.77 | TSHR (0.56) | GAAWDR5KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL16095355 | 0.76 | EGFR (0.51) | GAAWDR5KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1658401 | 0.75 | ROCK2 (0.49) | GAAKMT2ASMN1; SMN2MEN1HTT | |
| SCHEMBL10126927 | 0.74 | WDR5 (0.49) | WDR5KMT2APOLBKDM4EMAPT | |
| SCHEMBL1660509 | 0.74 | ROCK2 (0.48) | GAAWDR5KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17017299 | 0.74 | ALDH1A1 (0.52) | GAAWDR5KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |