Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 6/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476664 | 0.97 | TSHR (0.55) | TSHRCYP3A4TP53MAOBALDH1A1 | |
| SCHEMBL8472793 | 0.93 | TSHR (0.53) | TSHRCYP3A4TP53MAOBALDH1A1 | |
| SCHEMBL2207774 | 0.85 | NOS3 (0.44) | TSHRALDH1A1PRSS1NOS3NOS1 | |
| SCHEMBL2207957 | 0.84 | TSHR (0.43) | TSHRALDH1A1DHFRPRSS1NOS3 | |
| SCHEMBL5922467 | 0.82 | ALDH1A1 (0.49) | MAOBALDH1A1NOS1 | |
| SCHEMBL5280684 | 0.81 | MAOB (0.44) | TSHRMAOB | |
| SCHEMBL441825 | 0.80 | TSHR (0.79) | TSHRCYP3A4TP53MAOBALDH1A1 | |
| SCHEMBL29437009 | 0.80 | TSHR (0.79) | TSHRCYP3A4TP53MAOBALDH1A1 | |
| SCHEMBL5069212 | 0.79 | TSHR (0.82) | TSHRCYP3A4TP53MAOBALDH1A1 | |
| SCHEMBL18045584 | 0.79 | TSHR (0.82) | TSHRCYP3A4TP53MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |