Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | GFER | P55789 | 3/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15651949 | 0.85 | MAPT (0.49) | MAPTKDM4EGAAGFERRAD52 | |
| Hydrochloric Acid SCHEMBL3566180 | 0.84 | MAPT (0.49) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL30879199 | 0.81 | L3MBTL1 (0.49) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL30879130 | 0.81 | MEN1 (0.58) | MAPTSMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL16445747 | 0.76 | L3MBTL1 (0.53) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL1645940 | 0.75 | L3MBTL1 (0.49) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL30878749 | 0.75 | L3MBTL1 (0.49) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL17450442 | 0.75 | GAA (0.71) | MAPTKDM4EGAAGFERRAD52 | |
| SCHEMBL2236451 | 0.74 | L3MBTL3 (0.81) | MAPTKDM4EGAAGFERL3MBTL1 | |
| SCHEMBL16446432 | 0.74 | L3MBTL1 (0.50) | MAPTKDM4EGAAGFERRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |