Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | FOS | P01100 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521842 | 0.85 | ALDH1A1 (0.70) | ALDH1A1SYKMAPTSMN1; SMN2LMNA | |
| SCHEMBL29545771 | 0.85 | ALDH1A1 (0.70) | ALDH1A1SYKMAPTSMN1; SMN2LMNA | |
| SCHEMBL24885934 | 0.84 | RAB9A (0.50) | ALDH1A1SYKMAPTSMN1; SMN2LMNA | |
| SCHEMBL16370470 | 0.84 | MEN1 (0.49) | ALDH1A1SYKMAPTSMN1; SMN2LMNA | |
| SCHEMBL16446157 | 0.83 | ALDH1A1 (0.43) | ALDH1A1SYKMAPTSMN1; SMN2LMNA | |
| SCHEMBL24885909 | 0.81 | ALDH1A1 (0.44) | ALDH1A1SYKMAPTSMN1; SMN2LMNA | |
| SCHEMBL30078186 | 0.81 | ALDH1A1 (0.44) | ALDH1A1SYKMAPTSMN1; SMN2LMNA | |
| SCHEMBL19100943 | 0.81 | ALDH1A1 (0.51) | ALDH1A1SYKMAPTSMN1; SMN2MEN1 | |
| SCHEMBL2221978 | 0.81 | AHR (0.55) | ALDH1A1SYKLMNAMEN1KMT2A | |
| SCHEMBL5824244 | 0.81 | ALDH1A1 (0.47) | ALDH1A1SYKMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |