SCHEMBL30880475

SCHEMBL30880475

COc1cc(N)cc(-c2cncn2C)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.42
BRD9 Q9H8M2 1/20 0.40
MAPT P10636 2/20 0.40
GAA P10253 1/20 0.40
CYP1A1 P04798 1/20 0.40
CYP1B1 Q16678 1/20 0.40
GSK3B P49841 1/20 0.39
DYRK1A Q13627 1/20 0.39
PDPK1 O15530 1/20 0.39
HPGDS O60760 1/20 0.39
NTRK1 P04629 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
ALDH1A1 P00352 2/20 0.37
CYP3A4 P08684 1/20 0.37
HPGD P15428 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HSP90AA1 P07900 1/20 0.36
ATM Q13315 1/20 0.36
DHFR P00374 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28035340 0.78 IDO1 (0.64) IDO1BRD9MAPTGAAGSK3B
SCHEMBL24465876 0.75 MAPT (0.51) IDO1BRD9MAPTGSK3BDYRK1A
SCHEMBL6754289 0.74 MAPT (0.48) MAPTGAACYP1A1CYP1B1GSK3B
SCHEMBL3312215 0.74 IDO1 (0.41) IDO1BRD9GSK3BDYRK1AHPGDS
SCHEMBL27185954 0.73 ALDH1A1 (0.50) MAPTGAACYP1A1CYP1B1NTRK1
SCHEMBL30839799 0.73 ALDH1A1 (0.50) MAPTGAACYP1A1CYP1B1NTRK1
SCHEMBL7128025 0.72 IDO1 (0.66) IDO1BRD9DYRK1AHPGDSCCNA2
SCHEMBL30473398 0.72 IDO1 (0.66) IDO1BRD9DYRK1AHPGDSCCNA2
SCHEMBL15507182 0.72 ALDH1A1 (0.58) IDO1PDPK1HPGDSL3MBTL1ALDH1A1
SCHEMBL30132180 0.72 ALDH1A1 (0.58) IDO1PDPK1HPGDSL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024078513-A1 CONDENSED AZINES FOR TREATING CANCER CHENGDU ANTICANCER BIOSCIENCE , LTD. (CN) 2024-04-18 WO disclosed