Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30881767 | 0.82 | RPS6KB1 (0.36) | NTRK1MAPK14RPS6KB1CCNT1CDK9 | |
| SCHEMBL30881673 | 0.82 | NTRK1 (0.34) | NTRK1AURKARPS6KB1CCNT1CDK9 | |
| SCHEMBL30881727 | 0.80 | CCNT1 (0.35) | NTRK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30881884 | 0.78 | BTK (0.33) | NTRK1MAPK14CCNT1CDK9KIT | |
| SCHEMBL30881698 | 0.77 | NTRK1 (0.34) | NTRK1AURKARPS6KB1KITBTK | |
| SCHEMBL30881886 | 0.76 | JAK2 (0.34) | NTRK1RPS6KB1KITBTKJAK2 | |
| SCHEMBL30881702 | 0.75 | IRAK4 (0.32) | NTRK1CCNT1CDK9BTKJAK2 | |
| SCHEMBL30881670 | 0.75 | FGFR4 (0.33) | NTRK1CCNT1CDK9BTKJAK2 | |
| SCHEMBL30881765 | 0.75 | IRAK4 (0.34) | NTRK1CCNT1CDK9BTKJAK2 | |
| SCHEMBL30881667 | 0.74 | ROCK2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118026880-A | Aryl amide compound, pharmaceutical composition containing same and application thereof | 华东师范大学 | 2024-05-14 | — | — | CN | disclosed |