Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 4/20 | 0.88 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | IDH2 | P48735 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29204805 | 1.00 | XPO1 (0.88) | XPO1MEN1KMT2AIDH2LMNA | |
| SCHEMBL29204831 | 0.94 | XPO1 (0.77) | XPO1MEN1KMT2AIDH2LMNA | |
| SCHEMBL30883139 | 0.94 | XPO1 (0.77) | XPO1MEN1KMT2AIDH2LMNA | |
| SCHEMBL30883142 | 0.93 | XPO1 (1.00) | XPO1MEN1KMT2AIDH2LMNA | |
| SCHEMBL29204833 | 0.93 | XPO1 (1.00) | XPO1MEN1KMT2AIDH2LMNA | |
| SCHEMBL29204835 | 0.92 | XPO1 (0.74) | XPO1MEN1KMT2AIDH2LMNA | |
| SCHEMBL29204842 | 0.90 | XPO1 (0.80) | XPO1MEN1KMT2AMAPTTP53 | |
| SCHEMBL29204810 | 0.89 | XPO1 (0.70) | XPO1KMT2AIDH2LMNAMAPT | |
| SCHEMBL30883143 | 0.88 | XPO1 (0.69) | XPO1MEN1KMT2ALMNAMAPT | |
| SCHEMBL29204830 | 0.88 | XPO1 (0.69) | XPO1MEN1KMT2ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964578-A | Non-covalent CRM1 inhibitor and preparation method and application thereof | 四川大学 | 2024-05-03 | — | — | CN | disclosed |