Coumetarol

Coumetarol

SCHEMBL308833

COCC(c1c(O)c2ccccc2oc1=O)c1c(O)c2ccccc2oc1=O

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 3/20 0.68
CYP2C9 P11712 6/20 0.66
VKORC1 Q9BQB6 3/20 0.63
KDM4E B2RXH2 1/20 0.61
ALDH1A1 P00352 1/20 0.61
ALB P02768 1/20 0.61
PCSK7 Q16549 1/20 0.61
HSD17B10 Q99714 1/20 0.61
MEN1 O00255 1/20 0.61
KMT2A Q03164 1/20 0.61
ADORA3 P0DMS8 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8042698 0.83 CYP2C9 (0.86) NQO1CYP2C9VKORC1KDM4EALDH1A1
SCHEMBL1649847 0.81 CYP2C9 (0.50) NQO1CYP2C9KDM4EALDH1A1HSD17B10
SCHEMBL14078661 0.80 NQO1 (0.73) NQO1CYP2C9VKORC1
SCHEMBL32659670 0.80 VKORC1 (0.82) NQO1CYP2C9VKORC1
SCHEMBL310481 0.80 VKORC1 (0.82) NQO1CYP2C9VKORC1
Phenprocoumon SCHEMBL24500472 0.79 CYP2C9 (1.00) NQO1CYP2C9VKORC1KDM4EALDH1A1
Phenprocoumon SCHEMBL43031 0.79 CYP2C9 (1.00) NQO1CYP2C9VKORC1KDM4EALDH1A1
Phenprocoumon SCHEMBL29392123 0.79 CYP2C9 (1.00) NQO1CYP2C9VKORC1KDM4EALDH1A1
Phenprocoumon SCHEMBL24500477 0.79 CYP2C9 (1.00) NQO1CYP2C9VKORC1KDM4EALDH1A1
SCHEMBL18126686 0.79 NQO1 (0.78) NQO1CYP2C9VKORC1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 755 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
CN-103221070-A Shear controlled release for stenotic lesions and thrombolytic therapies HARVARD COLLEGE 2013-07-24 CN claimed
EP-2611466-A2 SHEAR CONTROLLED RELEASE FOR STENOTIC LESIONS AND THROMBOLYTIC THERAPIES President and Fellows of Harvard College (US) 2013-07-10 EP claimed
US-20130005683-A1 GLYCINE BETAINE AND ITS USE MESSADEK JALLAL (BE) 2013-01-03 US claimed
WO-2012074588-A2 SHEAR CONTROLLED RELEASE FOR STENOTIC LESIONS AND THROMBOLYTIC THERAPIES PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-06-07 WO claimed
US-8163806-B2 Controlled release of biologically active compounds from multi-armed oligomers BEZWADA BIOMEDICAL, LLC (US) 2012-04-24 US claimed
US-20120010284-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS BEZWADA BIOMEDICAL, LLC (US) 2012-01-12 US claimed
US-8034119-B2 Delivering an agent to a patient's body BOSTON SCIENTIFIC SCIMED, INC. (US) 2011-10-11 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1387649-B1 DELIVERING AN AGENT TO A PATIENT'S BODY BOSTON SCIENT LTD (BB) 2010-08-04 EP claimed
US-20040033223-A1 Glycine betaine and its use MESSADEK JALLAL (BE) 2004-02-19 US claimed
EP-1387649-A1 DELIVERING AN AGENT TO A PATIENT'S BODY SciMed Life Systems, Inc. (US) 2004-02-11 EP claimed
US-6685745-B2 Delivering an agent to a patient's body SCIMED LIFE SYSTEMS, INC. 2004-02-03 US claimed
EP-1309354-A2 THERAPEUTIC POLYESTERS AND POLYAMIDES Rutgers, The State University (US) 2003-05-14 EP claimed
US-20020173818-A1 Delivering an agent to a patient's body BOSTON SCIENTIFIC SCIMED, INC. 2002-11-21 US claimed
WO-2002091957-A1 DELIVERING AN AGENT TO A PATIENT'S BODY SCIMED LIFE SYSTEM, INC. (US) 2002-11-21 WO claimed
WO-2002062322-A2 GLYCINE BETAINE AND ITS USE AS ANTI-HEMORRHAGIC AGENT MESSADEK JALLAL (BE) 2002-08-15 WO claimed
US-20020071822-A1 Therapeutic polyesters and polyamides POLYMERIX CORPORATION 2002-06-13 US claimed
WO-2002009768-A2 THERAPEUTIC POLYESTERS AND POLYAMIDES RUTGERS, THE STATE UNIVERSITY (US) 2002-02-07 WO claimed
US-4334020-A Method of producing L-glutamic acid by fermentation AJINOMOTO COMPANY INCORPORATED (JP) 1982-06-08 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010284-A1 CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS FROM MULTI-ARMED OLIGOMERS MME, AADAC, LGMN NQO1 1517/4885CYP2C9 2823/4885VKORC1 4406/4885
US-20020071822-A1 Therapeutic polyesters and polyamides NPEPPS, PAICS, PUF60 NQO1 3920/4885CYP2C9 3155/4885VKORC1 4089/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.