Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 5/20 | 0.49 |
| ▸ | GABBR1 | Q9UBS5 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30890804 | 0.67 | MAPT (0.41) | CYP3A4MEN1TSHRKMT2AGAA | |
| Phenibut SCHEMBL340838 | 0.67 | GABBR2 (1.00) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| Phenibut SCHEMBL9545047 | 0.67 | GABBR2 (1.00) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| Phenibut SCHEMBL351501 | 0.67 | GABBR2 (1.00) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL9594903 | 0.67 | GABBR2 (0.44) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL2723647 | 0.66 | MAPT (0.43) | LMNATSHRGAAMAPT | |
| Phenibut SCHEMBL3053795 | 0.66 | GABBR2 (0.96) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| Phenibut SCHEMBL22831453 | 0.66 | GABBR2 (0.96) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL3997603 | 0.65 | MAPT (0.42) | LMNACYP3A4BLMCYP2C19TSHR | |
| SCHEMBL8556258 | 0.65 | MAPT (0.38) | LMNATSHRGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278166-A | 4-amino-3-heteroaryl butyric acid compounds, compositions, and their use for treating disorders involving a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5214063-A | 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5162364-A | Treatment of spastic and senescence disorders | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |