Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182185 | 0.75 | RET (0.41) | DAPK3MAP4K4PAK4ABL1LCK | |
| SCHEMBL20163009 | 0.75 | MTOR (0.42) | DAPK3MAP4K4PAK4ABL1LCK | |
| SCHEMBL30892143 | 0.73 | ADORA2A (0.40) | ADKPIK3CDPI4KAPI4K2BPI4K2A | |
| SCHEMBL21127668 | 0.72 | PI4KA (0.42) | DAPK3MAP4K4ABL1LCKFYN | |
| SCHEMBL30544134 | 0.71 | ADORA2A (0.54) | LCKRETKDRPIK3CDPI4KA | |
| SCHEMBL6364016 | 0.71 | ADORA2A (0.54) | LCKRETKDRPIK3CDPI4KA | |
| SCHEMBL21942686 | 0.69 | ADORA2A (0.45) | LCKRETKDRADKPIK3CD | |
| SCHEMBL23469011 | 0.68 | PIK3CD (0.45) | RETKDRADKPIK3CDMEN1 | |
| SCHEMBL24971532 | 0.67 | DHFR (0.46) | ADKPIK3CDPI4KAPI4K2BPI4K2A | |
| SCHEMBL21122549 | 0.66 | METTL3 (0.39) | RETLRRK2ADKPIK3CDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4424311-A2 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation (US) | 2024-09-04 | — | — | EP | disclosed |
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |