Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.37 |
| ▸ | CES1 | P23141 | 3/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11208938 | 0.77 | MCL1 (0.44) | LMNAMAPTALDH1A1L3MBTL1MCL1 | |
| SCHEMBL9648407 | 0.76 | MCL1 (0.43) | LMNAMAPTALDH1A1L3MBTL1MCL1 | |
| SCHEMBL15657353 | 0.73 | MCL1 (0.41) | LMNAMAPTALDH1A1L3MBTL1MCL1 | |
| SCHEMBL12083379 | 0.73 | LMNA (0.38) | LMNAMAPTALDH1A1L3MBTL1MCL1 | |
| SCHEMBL14421361 | 0.71 | LMNA (0.46) | LMNAALDH1A1CES2CES1DAO | |
| SCHEMBL12083412 | 0.71 | LMNA (0.42) | LMNAMAPTALDH1A1L3MBTL1MCL1 | |
| SCHEMBL8151048 | 0.70 | LMNA (0.48) | LMNAMAPTALDH1A1L3MBTL1CES2 | |
| SCHEMBL402908 | 0.69 | CETP (0.46) | LMNAALDH1A1CES2CES1DAO | |
| SCHEMBL8535808 | 0.68 | LMNA (0.40) | LMNAMAPTALDH1A1CES2CES1 | |
| SCHEMBL9718676 | 0.67 | LMNA (0.46) | LMNAMAPTALDH1A1L3MBTL1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917215-A | Fah gene knockout mouse capable of recovering Fah gene expression in specific cells and preparation method and application thereof | 中国科学院分子细胞科学卓越创新中心 | 2024-04-23 | — | — | CN | disclosed |