Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | STK17B | O94768 | 1/20 | 0.31 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31679495 | 0.79 | KCNH2 (0.35) | KCNH2NLRP3MAPK8 | |
| SCHEMBL30895758 | 0.78 | NLRP3 (0.68) | KCNH2NLRP3CACNA1B | |
| SCHEMBL30895753 | 0.77 | POLB (0.43) | POLBMAPK1ATMGFERKDM4E | |
| SCHEMBL22535987 | 0.66 | TDP1 (0.46) | POLBMAPK1ATMEPHX1GFER | |
| SCHEMBL1670964 | 0.66 | BTK (0.47) | EPHX1L3MBTL1CA1CA2 | |
| SCHEMBL21423769 | 0.66 | BTK (0.47) | EPHX1L3MBTL1CA1CA2 | |
| SCHEMBL1542182 | 0.66 | BTK (0.47) | EPHX1L3MBTL1CA1CA2 | |
| SCHEMBL741312 | 0.66 | BTK (0.47) | EPHX1L3MBTL1CA1CA2 | |
| SCHEMBL1542181 | 0.66 | BTK (0.47) | EPHX1L3MBTL1CA1CA2 | |
| SCHEMBL20178496 | 0.66 | BTK (0.47) | EPHX1L3MBTL1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024090469-A1 | FUSED PYRIDAZINE DERIVATIVE | アステラス製薬株式会社 | 2024-05-02 | — | — | WO | disclosed |