SCHEMBL30898237

SCHEMBL30898237

CC(C)(C)OC(=O)Nc1ccccc1Cn1cnc2c(Cl)nc(Cl)nc21

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC29A1 Q99808 1/20 0.52
YTHDC1 Q96MU7 10/20 0.49
HDAC1 Q13547 6/20 0.49
HDAC2 Q92769 6/20 0.49
HDAC3 O15379 5/20 0.49
HDAC4 P56524 5/20 0.49
HDAC7 Q8WUI4 5/20 0.49
HDAC10 Q969S8 5/20 0.49
HDAC11 Q96DB2 5/20 0.49
HDAC8 Q9BY41 5/20 0.49
HDAC6 Q9UBN7 5/20 0.49
HDAC9 Q9UKV0 5/20 0.49
HDAC5 Q9UQL6 5/20 0.49
NCOR2 Q9Y618 2/20 0.43
P2RX7 Q99572 2/20 0.43
MCL1 Q07820 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26347131 0.81 HDAC6 (0.56) YTHDC1HDAC1HDAC2HDAC3HDAC4
SCHEMBL17150783 0.77 P2RX7 (0.45) YTHDC1HDAC1HDAC2HDAC3HDAC4
SCHEMBL22412661 0.75 P2RX7 (0.55) YTHDC1HDAC1HDAC2HDAC3HDAC4
SCHEMBL26348187 0.74 STK17B (0.49) YTHDC1HDAC1HDAC2HDAC3HDAC4
SCHEMBL22345218 0.74 YTHDC1 (0.54) YTHDC1P2RX7
SCHEMBL22345214 0.74 YTHDC1 (0.75) YTHDC1
SCHEMBL27388379 0.73 YTHDC1 (0.68) YTHDC1HDAC1HDAC2HDAC3HDAC4
SCHEMBL22345205 0.72 YTHDC1 (0.52) YTHDC1HDAC1HDAC2HDAC3HDAC4
SCHEMBL30898282 0.72 YTHDC1 (0.72) YTHDC1HDAC1HDAC2HDAC3HDAC4
SCHEMBL22347138 0.72 HDAC6 (0.56) YTHDC1HDAC1HDAC2HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4461731-A1 LIGANDS OF THE M6A-RNA READERS Universität Zürich (CH) 2024-11-13 EP disclosed
WO-2024105159-A1 LIGANDS OF THE M6A-RNA READERS UNIVERSITY OF ZURICH (CH) 2024-05-23 WO disclosed