Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 10/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | PDE8A | O60658 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22345218 | 0.86 | YTHDC1 (0.54) | YTHDC1ADORA2AP2RX7CNR2 | |
| SCHEMBL30898282 | 0.84 | YTHDC1 (0.72) | YTHDC1P2RX7HDAC4HDAC1HDAC6 | |
| SCHEMBL30898278 | 0.81 | YTHDC1 (0.68) | YTHDC1ADORA2AP2RX7HDAC1HDAC2 | |
| SCHEMBL183057 | 0.81 | YTHDC1 (0.68) | YTHDC1ADORA2AP2RX7HDAC1HDAC2 | |
| SCHEMBL22345214 | 0.81 | YTHDC1 (0.75) | YTHDC1ADORA2APDE8AHSP90AA1HSP90AB1 | |
| SCHEMBL22345216 | 0.76 | LMNA (0.52) | YTHDC1ADORA2AP2RX7 | |
| SCHEMBL5465713 | 0.76 | P2RX7 (0.56) | YTHDC1ADORA2AP2RX7HDAC4HDAC1 | |
| SCHEMBL1578361 | 0.74 | PDE8A (0.51) | YTHDC1ADORA2AP2RX7HDAC4HDAC1 | |
| SCHEMBL3641506 | 0.74 | HDAC6 (0.55) | YTHDC1P2RX7HDAC4HDAC1HDAC6 | |
| SCHEMBL5461215 | 0.73 | HDAC6 (0.60) | YTHDC1P2RX7HDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12319694-B2 | Heterocyclic nitrogen-containing purine derivatives, pharmaceutical preparations containing these derivatives and their use in neuroprotection | UNIVERZITA PALACKEHO (CZ) | 2025-06-03 | — | — | US | disclosed |
| EP-3924353-B1 | HETEROCYCLIC NITROGEN-CONTAINING PURINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION | UNIV PALACKEHO (CZ) | 2024-04-24 | — | — | EP | disclosed |
| US-20220127269-A1 | HETEROCYCLIC NITROGEN-CONTAINING PURINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION | UNIVERZITA PALACKEHO (CZ) | 2022-04-28 | — | — | US | disclosed |
| EP-3924353-A1 | HETEROCYCLIC NITROGEN-CONTAINING PURINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION | Univerzita Palackého (CZ) | 2021-12-22 | — | — | EP | disclosed |
| WO-2020164648-A1 | HETEROCYCLIC NITROGEN-CONTAINING PURINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION | UNIVERZITA PALACKEHO (CZ) | 2020-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127269-A1 | HETEROCYCLIC NITROGEN-CONTAINING PURINE DERIVATIVES, PHARMACEUTICAL PREPARATIONS CONTAINING THESE DERIVATIVES AND THEIR USE IN NEUROPROTECTION | NME4, NLN, PNP | YTHDC1 2241/4885ADORA2A 12/4885P2RX7 111/4885 |
| US-12319694-B2 | Heterocyclic nitrogen-containing purine derivatives, pharmaceutical preparations containing these derivatives and their use in neuroprotection | NME4, NLN, PNP | YTHDC1 2241/4885ADORA2A 12/4885P2RX7 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.