Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 7/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 5/20 | 0.45 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | TYK2 | P29597 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30901933 | 0.81 | GPR88 (0.56) | NAMPTSMN1; SMN2MEN1NPC1MAPT | |
| SCHEMBL29730320 | 0.81 | GPR88 (0.56) | NAMPTSMN1; SMN2MEN1NPC1MAPT | |
| SCHEMBL24543221 | 0.81 | GPR88 (0.48) | NAMPTSMN1; SMN2MEN1NPC1MAPT | |
| SCHEMBL24543208 | 0.81 | SMN1; SMN2 (0.48) | NAMPTCYP3A4CYP2C9SCN3ACYP2D6 | |
| SCHEMBL29730103 | 0.81 | GPR88 (0.56) | NAMPTSMN1; SMN2MEN1NPC1MAPT | |
| SCHEMBL24543201 | 0.81 | GPR88 (0.56) | NAMPTSMN1; SMN2MEN1NPC1MAPT | |
| SCHEMBL30901934 | 0.81 | GPR88 (0.48) | NAMPTSMN1; SMN2MEN1NPC1MAPT | |
| SCHEMBL29730170 | 0.81 | SMN1; SMN2 (0.48) | NAMPTCYP3A4CYP2C9SCN3ACYP2D6 | |
| SCHEMBL27202114 | 0.80 | NAMPT (0.51) | NAMPTCYP3A4CYP2C9SCN3ACYP2D6 | |
| SCHEMBL27202118 | 0.80 | NAMPT (0.51) | NAMPTCYP3A4CYP2C9SCN3ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132450-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | ACADIA PHARMACEUTICALS INC. | 2024-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132450-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | GPR88, GPR65, GPR68 | NAMPT 4122/4885CYP3A4 3834/4885CYP2C9 3582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.