Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CIT | O14578 | 4/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 5/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30907489 | 0.93 | GABRA1 (0.38) | CITNUDT1AXLPRKCIJAK3 | |
| SCHEMBL30907228 | 0.84 | METAP2 (0.37) | ABL1MAP4K1 | |
| SCHEMBL30907522 | 0.83 | ABL1 (0.32) | ABL1MAP4K1 | |
| SCHEMBL30907357 | 0.81 | ABL1 (0.41) | CITNUDT1AXLPRKCIJAK3 | |
| SCHEMBL30907599 | 0.81 | NUDT1 (0.41) | CITNUDT1JAK1ABL1RPS6KA3 | |
| SCHEMBL30907101 | 0.81 | ABL1 (0.41) | CITNUDT1AXLPRKCIJAK3 | |
| SCHEMBL30907471 | 0.81 | ABL1 (0.41) | CITNUDT1AXLPRKCIJAK3 | |
| SCHEMBL30907110 | 0.77 | CIT (0.35) | CITNUDT1AXLPRKCIJAK3 | |
| SCHEMBL30907449 | 0.77 | CIT (0.35) | CITNUDT1AXLPRKCIJAK3 | |
| SCHEMBL30907314 | 0.75 | ABL1 (0.39) | ABL1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024097953-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-05-10 | — | — | WO | disclosed |