Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14800478 | 0.85 | GPR119 (0.48) | GPR119SMARCA2SMARCA4PBRM1LMNA | |
| SCHEMBL14801172 | 0.85 | GPR119 (0.48) | GPR119SMARCA2SMARCA4PBRM1LMNA | |
| SCHEMBL14800480 | 0.85 | GPR119 (0.48) | GPR119SMARCA2SMARCA4PBRM1LMNA | |
| SCHEMBL30867765 | 0.85 | GPR119 (0.51) | GPR119SMARCA2SMARCA4PBRM1LMNA | |
| SCHEMBL30911135 | 0.85 | GPR119 (0.46) | GPR119SMARCA2SMARCA4PBRM1LMNA | |
| SCHEMBL30911167 | 0.85 | GPR119 (0.46) | GPR119SMARCA2SMARCA4PBRM1LMNA | |
| SCHEMBL38654099 | 0.84 | GPR119 (0.46) | GPR119SMARCA2SMARCA4PBRM1LMNA | |
| SCHEMBL30911096 | 0.84 | SMARCA2 (0.48) | GPR119SMARCA2SMARCA4PBRM1LMNA | |
| SCHEMBL30867686 | 0.83 | HSD11B1 (0.35) | GPR119MET | |
| SCHEMBL30911102 | 0.79 | GPR119 (0.48) | GPR119SMARCA2SMARCA4PBRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598915-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076670-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |