Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867765 | 0.88 | GPR119 (0.51) | GPR119SMARCA2SMARCA4PBRM1MAPT | |
| SCHEMBL30911135 | 0.88 | GPR119 (0.46) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL30911167 | 0.88 | GPR119 (0.46) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL30911096 | 0.88 | SMARCA2 (0.48) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL30867813 | 0.86 | RET (0.44) | GPR119MAPTNPBWR1MCHR1PIK3CA | |
| SCHEMBL30911128 | 0.84 | GPR119 (0.45) | GPR119SMARCA2SMARCA4PBRM1MAPT | |
| SCHEMBL30911102 | 0.82 | GPR119 (0.48) | GPR119SMARCA2SMARCA4PBRM1ABCB1 | |
| SCHEMBL38654315 | 0.80 | NPBWR1 (0.42) | GPR119MAPTNPBWR1MCHR1LMNA | |
| SCHEMBL38653471 | 0.77 | MEN1 (0.52) | MAPTNPBWR1MCHR1LMNATP53 | |
| SCHEMBL38653165 | 0.73 | GPR119 (0.52) | GPR119SMARCA2SMARCA4PBRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260132143-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2026-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260132143-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | KRAS, NRAS, HRAS | GPR119 2581/4885SMARCA2 1765/4885SMARCA4 1844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.