Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30911205 | 1.00 | GPR119 (0.40) | GPR119MAPTPOLBLMNATP53 | |
| SCHEMBL30911221 | 1.00 | GPR119 (0.40) | GPR119MAPTPOLBLMNATP53 | |
| SCHEMBL38654464 | 0.93 | GPR119 (0.38) | GPR119MAPTLMNA | |
| SCHEMBL38653873 | 0.93 | GPR119 (0.38) | GPR119MAPTLMNA | |
| SCHEMBL38653779 | 0.86 | GPR119 (0.37) | GPR119MAPTPOLBLMNATP53 | |
| SCHEMBL30911137 | 0.85 | SMYD3 (0.33) | — | |
| SCHEMBL30872476 | 0.84 | POLB (0.48) | MAPTPOLBLMNATP53NPSR1 | |
| SCHEMBL30867690 | 0.81 | GRM5 (0.35) | GPR119MAPTLMNANPSR1 | |
| SCHEMBL30867853 | 0.81 | GRM5 (0.35) | GPR119MAPTLMNANPSR1 | |
| SCHEMBL38654243 | 0.78 | LMNA (0.47) | MAPTPOLBLMNATP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598915-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076670-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |