Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 13/20 | 0.33 |
| ▸ | SMO | Q99835 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.31 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30911205 | 0.85 | GPR119 (0.40) | — | |
| SCHEMBL30911162 | 0.85 | GPR119 (0.40) | — | |
| SCHEMBL30911221 | 0.85 | GPR119 (0.40) | — | |
| SCHEMBL38654464 | 0.79 | GPR119 (0.38) | — | |
| SCHEMBL38653873 | 0.79 | GPR119 (0.38) | — | |
| SCHEMBL30872476 | 0.72 | POLB (0.48) | — | |
| SCHEMBL38653779 | 0.71 | GPR119 (0.37) | — | |
| Trifluoroacetic Acid SCHEMBL30867877 | 0.70 | MET (0.37) | — | |
| SCHEMBL38653054 | 0.70 | ALDH1A1 (0.39) | ALOX15 | |
| Trifluoroacetic Acid SCHEMBL30911210 | 0.68 | PDE9A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598915-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076670-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |