Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867823 | 1.00 | GPR119 (0.37) | GPR119CCNE1CDK2PIK3CDGSK3B | |
| SCHEMBL38654232 | 0.89 | LMNA (0.36) | TP53LMNATHRB | |
| SCHEMBL30867732 | 0.85 | TP53 (0.48) | TP53LMNATHRB | |
| SCHEMBL38653376 | 0.78 | GPR119 (0.37) | GPR119TP53LMNA | |
| SCHEMBL30911221 | 0.77 | GPR119 (0.40) | GPR119TP53LMNA | |
| SCHEMBL30911205 | 0.77 | GPR119 (0.40) | GPR119TP53LMNA | |
| SCHEMBL30911162 | 0.77 | GPR119 (0.40) | GPR119TP53LMNA | |
| SCHEMBL38654024 | 0.77 | CHRM2 (0.34) | GPR119TP53LMNATHRB | |
| SCHEMBL38653779 | 0.76 | GPR119 (0.37) | GPR119TP53LMNATHRB | |
| SCHEMBL38654464 | 0.75 | GPR119 (0.38) | GPR119LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598915-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076670-A2 | TETHERED HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |