Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | MYT1 | Q01538 | 1/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17925769 | 0.86 | FAAH (0.42) | GAACSNK1D | |
| SCHEMBL30913152 | 0.83 | POLB (0.40) | — | |
| SCHEMBL26602775 | 0.79 | PRMT5 (0.35) | PRMT5WDR77CREBBPCDK1MYT1 | |
| SCHEMBL26645670 | 0.73 | PRMT5 (0.41) | PRMT5WDR77CREBBPGRM5CSNK1D | |
| SCHEMBL29261202 | 0.71 | P2RX7 (0.51) | P2RX7 | |
| SCHEMBL20595880 | 0.70 | CREBBP (0.42) | PRMT5WDR77CREBBP | |
| SCHEMBL28558608 | 0.68 | CREBBP (0.34) | PRMT5WDR77CREBBPGRM5CDK1 | |
| SCHEMBL17925617 | 0.68 | CREBBP (0.34) | PRMT5WDR77CREBBPCDK1MYT1 | |
| SCHEMBL20596105 | 0.68 | CREBBP (0.34) | PRMT5WDR77CREBBPCDK1MYT1 | |
| SCHEMBL17936814 | 0.68 | KDM4E (0.51) | GAAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118103369-A | Pyridolactam derivatives, preparation method and application thereof | 浙江海正药业股份有限公司 | 2024-05-28 | — | — | CN | disclosed |
| WO-2023030478-A1 | PYRIDOLACTAM DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 浙江海正药业股份有限公司 | 2023-03-09 | — | — | WO | disclosed |