Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30919096 | 0.82 | DGAT2 (0.56) | ALDH1A1GAADGAT2NPC1SMN1; SMN2 | |
| SCHEMBL30919040 | 0.75 | DGAT2 (0.66) | ALDH1A1GAADGAT2KMT2AMEN1 | |
| SCHEMBL30919128 | 0.74 | DGAT2 (0.64) | DGAT2BACE1 | |
| SCHEMBL9923875 | 0.73 | ALDH1A1 (1.00) | ALDH1A1GAATHRBHPGDNPC1 | |
| SCHEMBL30919235 | 0.73 | DGAT2 (0.59) | DGAT2BACE1 | |
| SCHEMBL30919117 | 0.73 | DGAT2 (0.56) | DGAT2 | |
| SCHEMBL30919031 | 0.72 | PTGS1 (0.42) | ALDH1A1GAAHPGDKDM4EKMT2A | |
| SCHEMBL30919028 | 0.72 | PTGS1 (0.42) | ALDH1A1GAAHPGDKDM4EKMT2A | |
| SCHEMBL30919035 | 0.72 | DGAT2 (0.61) | DGAT2KMT2ABACE1 | |
| SCHEMBL20100085 | 0.72 | ALDH1A1 (0.67) | ALDH1A1GAATHRBHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612151-A1 | PREPARATION OF IMIDAZOPYRIDINE AND IMIDAZOPYRIDAZINE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024097573-A1 | PREPARATION OF IMIDAZOPYRIDINE AND IMIDAZOPYRIDAZINE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-05-10 | — | — | WO | disclosed |