Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 9/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604256 | 0.84 | SMN1; SMN2 (0.63) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3222155 | 0.84 | HSP90AA1 (0.68) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL27875880 | 0.84 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10958445 | 0.83 | SMN1; SMN2 (0.62) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4039662 | 0.82 | TSHR (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL11319860 | 0.81 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1992777 | 0.81 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5805980 | 0.81 | ALDH1A1 (0.56) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL16697354 | 0.81 | SMN1; SMN2 (0.60) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13174946 | 0.81 | HSP90AA1 (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028622-B | Cyanine probe based on 4-amino-2-mercaptopyrimidine-5-carboxylic acid ethyl ester, and preparation method and application thereof | 常州大学 | 2023-08-22 | — | — | CN | claimed |
| CN-115028622-A | Cyanine probe based on 4-amino-2-mercaptopyrimidine-5-carboxylic acid ethyl ester and preparation method and application thereof | 常州大学 | 2022-09-09 | — | — | CN | claimed |
| CN-114316096-A | Functionalized polyolefin elastomer and preparation method thereof | 常州汉韦聚合物有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-115028622-B | Cyanine probe based on 4-amino-2-mercaptopyrimidine-5-carboxylic acid ethyl ester, and preparation method and application thereof | 常州大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-115028622-B | Cyanine probe based on 4-amino-2-mercaptopyrimidine-5-carboxylic acid ethyl ester, and preparation method and application thereof | 常州大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-115028622-B | Cyanine probe based on 4-amino-2-mercaptopyrimidine-5-carboxylic acid ethyl ester, and preparation method and application thereof | 常州大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-115028622-A | Cyanine probe based on 4-amino-2-mercaptopyrimidine-5-carboxylic acid ethyl ester and preparation method and application thereof | 常州大学 | 2022-09-09 | — | — | CN | disclosed |
| CN-115028622-A | Cyanine probe based on 4-amino-2-mercaptopyrimidine-5-carboxylic acid ethyl ester and preparation method and application thereof | 常州大学 | 2022-09-09 | — | — | CN | disclosed |
| CN-115028622-A | Cyanine probe based on 4-amino-2-mercaptopyrimidine-5-carboxylic acid ethyl ester and preparation method and application thereof | 常州大学 | 2022-09-09 | — | — | CN | disclosed |
| CN-114316096-A | Functionalized polyolefin elastomer and preparation method thereof | 常州汉韦聚合物有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-107849059-B | 7-phenylethylamino-4H-pyrimido [4,5-D ] [1,3] oxazin-2-one compounds and their use as inhibitors of mutant IDH1 | 伊莱利利公司 | 2020-04-28 | — | — | CN | disclosed |
| EP-1228070-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-07 | — | — | EP | disclosed |
| EP-1226144-A1 | ALKYLAMINO SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-31 | — | — | EP | disclosed |
| CN-1324360-A | Bicyclic nitrogen heterocycles | HOFFMANN LA ROCHE (CH) | 2001-11-28 | — | — | CN | disclosed |
| EP-1123295-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| WO-2001029041-A1 | ALKYLAMINO SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
| WO-2001029042-A1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |
| US-6150373-A | AMINO-SUBSTITUTED DIHYDROPYRIMIDO(4,5-D)PYRIMIDINONE DERIVATIVES; INHIBITORS OF THE T-CELL TYROSINE KINASE P56LCK; IMMUNOSUPPRESSANTS; ANTIINFLAMMATORY/-CARCINOGENIC AGENTS; BRONCHOPULMONARY, DERMATOLOGICAL AND CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-2000024744-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-04 | — | — | WO | disclosed |
| EP-0046856-A2 | Process for preparing 4-amino-2-mercapto-pyrimidines | HÜLS TROISDORF AKTIENGESELLSCHAFT (DE) | 1982-03-10 | — | — | EP | disclosed |