Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.51 |
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923204 | 1.00 | TYK2 (0.51) | TYK2JAK1DHODHERBB2LCK | |
| SCHEMBL29883000 | 0.91 | TYK2 (0.60) | TYK2JAK1 | |
| SCHEMBL27294015 | 0.79 | TYK2 (0.59) | TYK2JAK1 | |
| SCHEMBL27417191 | 0.77 | JAK3 (0.49) | TYK2JAK1KDR | |
| SCHEMBL31711619 | 0.77 | TYK2 (0.52) | TYK2JAK1 | |
| SCHEMBL27293373 | 0.75 | JAK1 (0.44) | TYK2JAK1 | |
| SCHEMBL27293253 | 0.74 | TYK2 (0.49) | TYK2JAK1ALOX15HSD17B10 | |
| SCHEMBL31711666 | 0.74 | TYK2 (0.49) | TYK2JAK1ALOX15HSD17B10 | |
| SCHEMBL27293368 | 0.74 | TYK2 (0.45) | TYK2JAK1 | |
| SCHEMBL30923245 | 0.73 | TYK2 (0.43) | TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4618975-A2 | INHIBITORS OF TYK2 | Vyrnwy Therapeutics, Inc. (US) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024107658-A2 | INHIBITORS OF TYK2 | VYRNWY THERAPEUTICS, INC. (US) | 2024-05-23 | — | — | WO | disclosed |