Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 9/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.38 |
| ▸ | MERTK | Q12866 | 5/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30923897 | 0.76 | BTK (0.45) | BTKMAPK8MAPK9IRAK4 | |
| SCHEMBL30923890 | 0.74 | FLT3 (0.49) | EGFRTYRO3MERTKGAS6FLT3 | |
| SCHEMBL8599315 | 0.73 | POLB (0.46) | — | |
| SCHEMBL24344307 | 0.72 | CYP3A4 (0.45) | EGFRIRAK4 | |
| SCHEMBL24344303 | 0.71 | IRAK4 (0.43) | EGFRIRAK4 | |
| SCHEMBL29534716 | 0.71 | IRAK4 (0.43) | EGFRIRAK4 | |
| SCHEMBL29164534 | 0.67 | SIRT5 (0.47) | — | |
| SCHEMBL30892313 | 0.66 | MAPK8 (0.65) | TYRO3MERTKGAS6MAPK8MAPK9 | |
| SCHEMBL18113766 | 0.66 | ALDH1A1 (0.42) | — | |
| SCHEMBL17167992 | 0.65 | MERTK (0.47) | TYRO3MERTKGAS6MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024105364-A1 | HETEROCYCLIC INHIBITORS OF CDC-LIKE KINASES | CURADEV PHARMA LTD (GB) | 2024-05-23 | — | — | WO | disclosed |