Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.35 |
| ▸ | LPL | P06858 | 7/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 7/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12078031 | 0.90 | BACE1 (0.38) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL30935204 | 0.88 | BACE1 (0.37) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL30935124 | 0.85 | BACE1 (0.36) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL30926385 | 0.84 | CDC7 (0.39) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL12078315 | 0.84 | CDC7 (0.39) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL27159925 | 0.82 | LPL (0.37) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL29914835 | 0.82 | LPL (0.37) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL30935054 | 0.77 | USP30 (0.41) | BACE1PRMT5WDR77ROCK1 | |
| SCHEMBL12077723 | 0.75 | BACE1 (0.42) | BACE1LPLLIPGPRMT5WDR77 | |
| SCHEMBL24457643 | 0.74 | TDP2 (0.43) | BACE1CA1CA2CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125464-A1 | TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-20 | — | — | WO | disclosed |