Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935122 | 0.90 | USP30 (0.41) | RORCCDK1CCNB2CCNB1GSK3B | |
| SCHEMBL30935054 | 0.81 | USP30 (0.41) | RORCALKGPR119USP30DDB1 | |
| SCHEMBL16086112 | 0.77 | USP30 (0.45) | RORCGPR119USP30NR1H2ESR2 | |
| SCHEMBL16086822 | 0.77 | USP30 (0.45) | RORCGPR119USP30NR1H2ESR2 | |
| SCHEMBL16086326 | 0.77 | USP30 (0.45) | RORCGPR119USP30NR1H2ESR2 | |
| SCHEMBL1466048 | 0.76 | ESR2 (0.42) | RORCCDK1CCNB2CCNB1GSK3B | |
| SCHEMBL17586451 | 0.75 | RORC (0.42) | RORCCDK1CCNB2CCNB1GSK3B | |
| SCHEMBL26176388 | 0.75 | ALK (0.42) | RORCALKGPR119USP30PDK2 | |
| SCHEMBL31694099 | 0.75 | ALK (0.42) | RORCALKGPR119USP30PDK2 | |
| SCHEMBL6524496 | 0.74 | GPR119 (0.41) | RORCALKGPR119USP30CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125464-A1 | TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-20 | — | — | WO | disclosed |