Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.52 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.52 |
| ▸ | TDP2 | O95551 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935140 | 0.78 | MAPKAPK2 (0.53) | PARP10PARP11TDP2BTKITK | |
| SCHEMBL30935043 | 0.78 | PARP10 (0.45) | PARP10PARP11TDP2BTKITK | |
| SCHEMBL30935080 | 0.77 | MAPKAPK2 (0.55) | PARP10PARP11TDP2BTKITK | |
| SCHEMBL30934991 | 0.77 | MAPKAPK2 (0.66) | PARP10PARP11TDP2BTKITK | |
| SCHEMBL30935237 | 0.77 | MAPKAPK2 (0.52) | PARP10PARP11TDP2BTKITK | |
| SCHEMBL30935410 | 0.77 | MAPKAPK2 (0.52) | PARP10PARP11TDP2BTKITK | |
| SCHEMBL30935284 | 0.76 | MAPKAPK2 (0.46) | PARP10PARP11TDP2BTKMAPKAPK2 | |
| SCHEMBL30935233 | 0.76 | MAPKAPK2 (0.51) | PARP10PARP11TDP2BTKITK | |
| SCHEMBL30935149 | 0.76 | MAPKAPK2 (0.47) | PARP10PARP11TDP2BTKITK | |
| SCHEMBL30935156 | 0.75 | TGM2 (0.53) | BTKITKJAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125464-A1 | TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-20 | — | — | WO | disclosed |