Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | CPS1 | P31327 | 2/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3079279 | 0.90 | ALDH1A1 (0.49) | ALDH1A1CPS1PROKR1GRIN2BOPRM1 | |
| SCHEMBL3084860 | 0.87 | HPGD (0.51) | ALDH1A1CPS1PROKR1GRIN2BOPRM1 | |
| SCHEMBL3080049 | 0.87 | PROKR1 (0.53) | ALDH1A1PROKR1GRIN2BCYP3A4CYP1A2 | |
| SCHEMBL3096010 | 0.86 | ALDH1A1 (0.63) | ALDH1A1PROKR1GRIN2BCYP3A4CYP1A2 | |
| SCHEMBL3073809 | 0.85 | ALDH1A1 (0.51) | ALDH1A1CPS1PROKR1GRIN2BCYP3A4 | |
| SCHEMBL3091158 | 0.85 | ALDH1A1 (0.52) | ALDH1A1PROKR1GRIN2BCYP3A4CYP1A2 | |
| SCHEMBL3080412 | 0.82 | ALDH1A1 (0.47) | ALDH1A1GRIN2BOPRM1OPRD1OPRK1 | |
| SCHEMBL3086823 | 0.82 | NPC1 (0.49) | ALDH1A1GRIN2BOPRM1OPRD1OPRK1 | |
| SCHEMBL3086692 | 0.81 | ALDH1A1 (0.47) | ALDH1A1GRIN2BOPRM1OPRD1OPRK1 | |
| SCHEMBL3081032 | 0.81 | CYP3A4 (0.56) | ALDH1A1CYP3A4CYP1A2USP2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790898-B2 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2010-09-07 | — | — | US | claimed |
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-07-26 | — | — | US | claimed |
| US-7790898-B2 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2010-09-07 | — | — | US | disclosed |
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | GRUENENTHAL GMBH (DE) | 2007-07-26 | — | — | US | disclosed |
| EP-1771417-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010577-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173533-A1 | Substituted 3-phenylpiperidine compounds, their preparation and use | OPRK1, OPRD1, OPRL1 | ALDH1A1 698/4885CPS1 1990/4885PROKR1 3842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.