Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30937596 | 0.86 | PER2 (0.45) | PER2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30937538 | 0.84 | PER2 (0.45) | PER2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30937764 | 0.81 | BRD4 (0.50) | PER2BRD4GAAKMT2AMEN1 | |
| SCHEMBL3307027 | 0.81 | BRD4 (0.50) | PER2BRD4GAAKMT2AMEN1 | |
| SCHEMBL30937691 | 0.77 | ACE (0.43) | GAAKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL30937645 | 0.76 | GPR139 (0.47) | PER2MAPK1THRB | |
| SCHEMBL30937712 | 0.76 | ACE (0.43) | CASP3BRD4GAAKMT2AMEN1 | |
| SCHEMBL29546687 | 0.75 | CTSG (0.45) | BRD4GAACDK5CDK5R1ALDH1A1 | |
| SCHEMBL30937744 | 0.74 | ACE (0.52) | GAAKMT2ACDK5CDK5R1MEN1 | |
| SCHEMBL29546562 | 0.72 | MAPK1 (0.55) | PER2MAPK1CDK5CDK5R1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594307-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2025-08-06 | — | — | EP | disclosed |
| WO-2024073426-A1 | 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-04-04 | — | — | WO | disclosed |